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Understanding Menopause and Perimenopause: How Doctors Make the Diagnosis

Louise
Louise Published December 4, 2024
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As women approach their late 40s and early 50s, many begin to experience changes that might suggest the onset of menopause or its precursor, perimenopause. These transitions can be accompanied by a range of symptoms that affect physical, emotional, and mental health. But how exactly do doctors determine if a woman is in menopause or perimenopause? Let’s explore the combination of symptom assessments and lab tests commonly used to make these determinations.


Symptoms Leading to Testing

The journey into menopause typically starts with perimenopause, a phase that can last several years. During this time, women might notice signs such as:

  • Irregular periods
  • Hot flashes
  • Night sweats
  • Mood swings
  • Sleep disturbances
  • Vaginal dryness

When these symptoms appear, it can prompt a visit to the doctor, who may suggest lab testing to confirm whether these changes are indeed related to menopause or if another condition might be causing them.


Key Hormone Tests

To assess menopause status, doctors often look at various hormone levels, which fluctuate significantly during this transition.

Follicle-Stimulating Hormone (FSH)

FSH is one of the most commonly tested hormones to assess menopause status. As ovarian function declines with age, the levels of estrogen decrease, causing the pituitary gland to release more FSH to stimulate the ovaries. An elevated FSH level, typically over 30 mIU/mL, is a strong indicator that a woman is in menopause or perimenopause. However, FSH levels can fluctuate greatly during perimenopause, so a single test might not be definitive.

Estradiol, a form of estrogen, is another key hormone measured to assess menopause. Low levels of estradiol (typically less than 30 pg/mL) alongside high levels of FSH can confirm that menopause is likely. Estradiol levels are lower during menopause due to decreased ovarian production of the hormone.

Luteinizing Hormone (LH) Levels

LH is another hormone that can be tested, although it’s less commonly used for diagnosing menopause than FSH. Like FSH, LH levels increase as estrogen levels decline. High levels can support the diagnosis of menopause but are not usually as diagnostic as FSH levels.

Thyroid Function Tests

Sometimes, symptoms of menopause such as fatigue, mood swings, and sleep disturbances can mimic thyroid disorders. Testing thyroid function can help exclude thyroid issues as the cause of these symptoms.

Antimüllerian Hormone (AMH) Levels

AMH levels can also provide information about ovarian reserve and are useful in assessing the onset of menopause. Low or undetectable AMH levels indicate that the ovarian reserve is low, consistent with menopause.


Other Diagnostic Tools

In addition to hormone testing, doctors might check thyroid function to rule out thyroid disorders, which can mimic some menopausal symptoms. A complete assessment involves looking at the full spectrum of symptoms and medical history.


Holistic Diagnosis Approach

Diagnosing menopause or perimenopause isn’t solely about numbers on a lab test. Doctors consider a woman’s age, symptoms, menstrual history, and lab results collectively. This comprehensive approach ensures that other potential health issues aren’t overlooked and that the diagnosis of menopause is accurate.


Menopause and perimenopause are significant life transitions that require understanding and patience. If you’re experiencing symptoms that disrupt your daily life, a consultation with your healthcare provider can offer insights and guidance. With proper diagnosis and support, women can manage this natural phase of life with confidence and continue to enjoy a healthy, fulfilling lifestyle.

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